姓名：阿斯根

職稱：特聘研究員、博士生導(dǎo)師

地址：華東理工大學(xué)徐匯校區(qū)實(shí)驗(yàn)十二樓504室

郵箱：sigen.a@ecust.edu.cn

個人經(jīng)歷

主要研究方向——功能高分子生物醫(yī)用材料開發(fā)及其應(yīng)用

·     可控活性聚合技術(shù)合成的新型超支化PEG聚合物及其功能化應(yīng)用

·     天然高分子聚合物（透明質(zhì)酸、硫酸軟骨素、殼聚糖、明膠、膠原、角蛋白等）的改性及功能化

·     功能性可注射水凝膠在組織工程學(xué)、軟組織傷口愈合、軟骨/骨修復(fù)、干細(xì)胞載體、藥物載體及 3D 打印方向的應(yīng)用

研究項(xiàng)目情況

·     愛爾蘭科學(xué)基金會（SFI）企業(yè)聯(lián)合資助項(xiàng)目，一種可用于胸骨粘合的新一代紫外交聯(lián)超支化聚β氨基酯組織交聯(lián)劑的構(gòu)建，2020，52277.75 歐元，項(xiàng)目主持。

·     愛爾蘭科學(xué)基金會（SFI）未來創(chuàng)新者項(xiàng)目，一種顛覆性的、非病毒基因編輯平臺技術(shù)用于遺傳疾病的治療，2019，217070 歐元，核心參與人員。

·     愛爾蘭科學(xué)基金會（SFI）項(xiàng)目，原位皮膚替代物結(jié)合基因療法修復(fù)皮膚創(chuàng)傷，2014，1180000 歐元，核心參與人員。

產(chǎn)業(yè)轉(zhuǎn)化項(xiàng)目情況

1.  新型透明質(zhì)酸凝膠型皮膚填充劑開發(fā)，項(xiàng)目主持；

2.  新型膠原蛋白皮膚填充劑的開發(fā)（無交聯(lián)劑體系），項(xiàng)目主持；

3.  原位交聯(lián)透明質(zhì)酸水凝膠結(jié)合臍血干細(xì)胞治療慢性傷口愈合，材料項(xiàng)目主持（北科生物合作項(xiàng)目）；

4.  原位交聯(lián)透明質(zhì)酸水凝膠結(jié)合間充質(zhì)干細(xì)胞治療軟骨愈合，材料項(xiàng)目主持（深圳大學(xué)合作項(xiàng)目）；

5.  原位交聯(lián)透明質(zhì)酸水凝膠結(jié)合倍他米松治療腰椎間盤突出引發(fā)的疼痛，材料項(xiàng)目主持（浙江大學(xué)一附院骨科合作項(xiàng)目）；

6.  原位交聯(lián)透明質(zhì)酸水凝膠膀胱黏膜保護(hù)劑的開發(fā)，材料項(xiàng)目主持（北京醫(yī)學(xué)泌尿科合作項(xiàng)目）

榮譽(yù)獎勵

1.  安徽省海外引才計(jì)劃青年百人學(xué)者（2023年）；

2.  中國留學(xué)基金委優(yōu)秀留學(xué)生獎學(xué)金（非公派）2019年獲獎?wù)撸ㄈ蛭灏倜?/span>

學(xué)術(shù)成果

累積發(fā)表第一/通訊作者（含共同）論文21篇，包括J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Adv. Func. Mater.等。申請國際PCT發(fā)明專利5件，授權(quán)中國發(fā)明專利3件。

1.   Milne, C., Song, R.,* Johnson, M., Zhao, C., Santoro, F., A, S.,* Lyu, J., Wang, W.*, ‘Dual-Modified Hyaluronic Acid for Tunable Double Crosslinked Hydrogel Adhesives’. Biomacromolecules, 2024, 25, 2645-2655, DOI: 10.1021/acs.biomac.4c00194.

2.   Song, R., Wang, X., Johnson, M., Milne, C., Lesniak-Podsiadlo, A., Li, Y., Lyu, J., Li, Z., Zhao, C., Yang, L., Lara-Sáez, I., A, S.,* Wang, W.*,‘Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion-Adhesion Balance’. Advanced Functional Materials, 2024, 202313322, DOI:10.1002/adfm.202313322.

3.  Ma, B., Shi, J., Zhang, Y., Li, Z., Yong, H., Zhou, Y.,* Liu, S.,* A, S.,* Zhou, D.*, Enzymatically Activatable Polymers for Disease Diagnosis and Treatment. Advanced Materials, 2023, 2306358, DOI: 10.1002/adma.202306358.

4.  Shi, J., Ma, B., Zhang, Y., Yong, H., Li, Z., A, S.,* Huang, H.,* Zhou, D.*, Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity. Chemistry of Materials, 2023, 35, 6573, DOI: 10.1021/acs.chemmater.3c01151.

5.   Li, Y., Wang, X., He, Z., Johnson, M., A, S.,* Lara-Sáez, I., Lyu, J.,* Wang, W.*, 3D Macrocyclic Structure Boosted Gene Delivery: Multi-cyclic Poly(β-Amino Ester)s from Step Growth Polymerization. Journal of the American Chemical Society, 2023, 145, 17187, DOI: 10.1021/jacs.3c04191.

6.   Wang, X., Johnson, M., Zhang, N., Shen, P., Yang, L., Milne, C., Lara-Saez, I., Song, R.,* A, S.,* Wang, W., Stimuli-responsive chitosan-based injectable hydrogel for ‘‘on-demand’’ drug release. Materials Advances, 2023, 4, 6439, DOI: 10.1039/d3ma00430a.

7.   Li, X., Xu, Q., Johnson, M., Wang X., Lyu, J., Li, Y., McMahon S., Greiser U., A, S.*, Wang, W.*, A Chondroitin Sulfate based Injectable Hydrogel for Delivery of Stem Cells in Cartilage Regeneration. BIOMATERIALS SCIENCE, 2021, 9, 4139, DOI: 10.1039/d1bm00482d.

8.  A, S., Xu, Q.*, Johnson, M., Creagh-Flynn, J., Venet, M., Zhou, D., Lara-Saez, I., Tai, H., Wang, W.*, An Injectable Multi-Responsive Hydrogel as Self-Healable and On-demand Dissolution Tissue Adhesive. APPLIED MATERIALS TODAY, 2021, 22, 100967, DOI: 10.1016/j.apmt.2021.100967.

9.   A, S., Lyu, J., Johnson, M., Creagh-Flynn, J., Zhou, D., Lara-Sez, I., Xu, Q.,* Tai, H., Wang, W.* , An Instant Gelation System as Self-Healable and Printable 3D Cell Culture Bio-Ink based on Dynamic Covalent Chemistry. ACS Applied Materials & Interfaces, 2020, 12, 35, 38918-38924, DOI: 10.1021/acsami.0c08567.

10. A, S., Zeng, M., Johnson, M., Creagh-Flynn, J., Xu, Q.,*, Tai, H., Wang, W.*, Green Synthetic Approach for Photo-Cross-Linkable Methacryloyl Hyaluronic Acid with a Tailored Substitution Degree. Biomacromolecules, 2020, 21, 2229-2235, DOI: 10.1021/acs.biomac.0c00196.

11. Yong, H., Miao, Y., A, S.,* Quan, D., Ivankovic, A., Singh, K., Zhang, J., Zhou, D., Wang, W.* , Branched Polystyrenes from a Suspension “Strathclyde” Polymerization Using a Vulcanization Accelerator as Chain Transfer Agent’. Polymer Chemistry, 2019, 10, 885-890, DOI: 10.1039/C8PY01639A.

12.  Xu, Q., A, S., Venet, M., Gao, Y., Zhou, D.*, Wang, W., Zeng, M., Rotella, C., Li, X., Wang, X., Lyu, J., Rodriguez, B. J., Wang, W.* ‘Bacterial-Resistant Single Chain Cyclized/Knotted Polymer Coatings. Angewandte Chemie International Edition, 2019, 131 (31), 10726-10730, DOI: 10.1002/anie.201904818. (co-first author)

13.  Xu, Q., Venet, M., Wang, W., Creagh-Flynn, J., Wang, X., Li, X., Gao, Y., Zhou, D., Zeng, M, Lara-Sáez, I., A, S.,* Tai, H., Wang, W.* , Versatile Hyperbranched Poly(β-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels.ACS Applied Materials & Interfaces, 2018, 10 (46), pp 39494–39504. DOI: 10.1021/acsami.8b15006.

14.  Xu, Q.; A, S.,; Gao, Y.; Guo, L.; Creagh-Flynn, J.; Zhou, D.; Greiser, U.; Dong, Y.; Wang, F.; Tai, H.; Liu, W.; Wang, W.*; Wang, W.* , A Hybrid Injectable Hydrogel from Hyperbranched PEG Macromer as a Stem Cell Delivery and Retention Platform for Diabetic Wound Healing. Acta Biomaterialia, 2018, 75, 63–74. DOI: 10.1016/j.actbio.2018.05.039. (IF=6.383) (co-first author)

15.  Xu, Q.; A, S.*; McMichael, P.; Creagh-Flynn, J.; Zhou, D.; Gao, Y.; Li, X.; Wang, X.; Wang, W.*, Double-Cross-Linked Hydrogel Strengthened by UV Irradiation from a Hyperbranched PEG-Based Trifunctional Polymer.ACS Macro Letters, 2018, 7 (5), 509–513. DOI: 10.1021/acsmacrolett.8b00138. (IF=6.131)

16. A, S.; Xu, Q.; McMichael, P.; Gao, Y.; Li, X.; Wang, X.; Greiser, U.; Zhou, D.; Wang, W.* , A Facile One-Pot Synthesis of Acrylated Hyaluronic Acid. Chemical Communications, 2018, 54 (9), 1081–1084. DOI: 10.1039/C7CC08648B. (IF=6.29)

17.  A, S.; Xu, Q.; Zhou, D.; Gao, Y.; Vasquez, J. M.; Greiser, U.; Wang, W.; Liu, W.; Wang, W.*, Hyperbranched PEG-Based Multi-NHS Polymer and Bioconjugation with BSA’. Polymer Chemistry, 2017, 8 (8), 1283–1287.DOI: 10.1039/C6PY01719C. (IF=4.927)

18. O'Keeffe Ahern, J., A, S., Zhou, D., Gao, Y., Lyu, J., Meng, Z., Cutlar, L., Pierucci, L., Wang, W.* , Brush-like Cationic Polymers with Low Charge Density for Gene Delivery. BIOMACROMOLECULES, 2018, 19, 1410-1415, DOI: 10.1021/acs.biomac.7b01267. (IF=5.65) (co-first author)

19. A, S., Y. Zhang, Z. Li, H. Xia, M. Xue, X. Liu, Y. Mu, Highly efficient and reversible iodine capture using a metalloporphyrin-based conjugated microporous polymer. Chemical Communications, 2014, 50, 8495–8498. DOI: 10.1039/C4CC01783H. (IF=6.29)

20. X. Liu, A, S., Y. Zhang, X. Luo, H. Xia, H. Li, Y. Mu, A porphyrin-linked conjugated microporous polymer with selective carbon dioxide adsorption and heterogeneous organocatalytic performances. RSC Advances, 2014, 4(13), 6447-6453. DOI: 10.1039/C3RA46988C. (IF=3.16)

21. A, S., X. Liu, H. Li, C. He, Y. Mu, Direct CH Arylation of Unactivated Arenes with Aryl Halides Promoted by Bis (imino) pyridine Derivatives. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2(10), 857-861. DOI: 10.1002/ajoc.201300129 (IF=2.53)