姓名：岑蓮 教授、博士生導(dǎo)師
地址：華東理工大學(xué)實(shí)驗(yàn)十二樓504室
座機(jī)：021-64252808
Email：liancen@ecust.edu.cn
【個(gè)人簡介】
教育背景：
01/2001--- 12/2003 博士 新加坡國立大學(xué)化工學(xué)院化學(xué)與生物分子系
09/1996--- 07/2000 學(xué)士（本科,化學(xué)工程/科技外語） 華東理工大學(xué)
工作經(jīng)歷：
09/2014--- 至今 教授 華東理工大學(xué)化工學(xué)院
06/2012--- 08/2014 副教授 華東理工大學(xué)化工學(xué)院
08/2006--- 05/2012 項(xiàng)目主管 組織工程國家工程研究中心
07/2005--- 03/2006 博士后 新加坡國立大學(xué)醫(yī)學(xué)院
01/2004--- 06/2005 Research Fellow 新加坡國立大學(xué)化工學(xué)院
【研究方向】
1.醫(yī)用可降解生物凝膠和組織再生應(yīng)用
2.微球的可控制備和生物醫(yī)學(xué)應(yīng)用
3.微載體的性能控制和細(xì)胞治療中的應(yīng)用
4.微納藥物緩釋制劑的工程化制備和應(yīng)用
【承擔(dān)項(xiàng)目】
1. 國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）課題 (2010CB944804) 課題名稱：基于牙齒發(fā)育原理的牙齒構(gòu)建與再生 課題負(fù)責(zé)人 2010年1月1日至2014年8月31日 經(jīng)費(fèi)：449萬元。
2. 國家自然科學(xué)基金（青年科學(xué)基金項(xiàng)目） (30900304) 項(xiàng)目名稱: 納米聚磷酸鹽顆粒改性聚α-羥基酸類組織工程支架材料以中合其降解的酸性產(chǎn)物. 項(xiàng)目負(fù)責(zé)人 2010年1月至2012年12月 經(jīng)費(fèi)：19萬。
3. 上海市浦江人才計(jì)劃 (07pj14110) 項(xiàng)目名稱：用聚磷酸鈉改性聚羥基乙酸組織工程用支架材料以消除支架降解酸性產(chǎn)物的炎癥影響. 項(xiàng)目負(fù)責(zé)人 2007年09月30日至2009年9月30日 經(jīng)費(fèi)：20萬元。
【主要成果】
1.發(fā)明創(chuàng)造名稱：一種生物可降解材料及其制備方法和用途
專利號：ZL 200910049605.9
發(fā)明人：岑蓮，曹誼林，劉偉，崔磊，李喆
2.發(fā)明創(chuàng)造名稱：一種殼寡糖和透明質(zhì)酸交聯(lián)凝膠的制備方法
專利號：ZL 201210338284.6
發(fā)明人：岑蓮，謝淑君，徐菊美
3.發(fā)明創(chuàng)造名稱：一種核殼結(jié)構(gòu)微載體及其制備方法
專利號：ZL 202210769838.1
發(fā)明人：岑蓮，武艷飛，吳偉騫，奚楨浩，朱志華
【近年來發(fā)表的代表性論文】
1. C. An, Y. Chen, Y. Wu, Z. Hu, H. Zhang, R. Liu, Y. Zhou*, L. Cen*, Manipulation of porous poly(L-lactide-co-ε-caprolactone) microcarriers via microfluidics for C2C12 expansion, International Journal of Biological Macromolecules, 242, (2023) https://doi.org/10.1016/j.ijbiomac.2023.124625.
2. Z. Jin, Y. Zhai, Y. Zhou, P. Guo, M. Chai, W. Tan, Y. Zhou *, L. Cen*, Regulation of mesenchymal stem cell osteogenic potential via microfluidic manipulation of microcarrier surface curvature, Chemical Engineering Journal. 448 (2022) DOI10.1016/j.cej.2022.137739.
3. Y. Wu, Y. Zheng, Z. Jin, S. Li, W. Wu, C. An, J. Guo, Z. Zhu, T. Zhou*, Y. Zhou*, L. Cen*, Controllable manipulation of alginate-gelatin core-shell microcarriers for HUMSCs expansion, International Journal of Biological Macromolecules. 216 (2022) 1-13.
4. W. Song, Z. Jin, X. Huang, Z. Xi*, X. Luo*, L. Cen*, Microfluidic-preparation of PLGA microcarriers with collagen patches for MSCs expansion and osteogenic differentiation, European Polymer Journal. 170 (2022) DOI10.1016/j.eurpolymj.2022.111177.
5. J. Zhou, Y. Zhai, J. Xu, T. Zhou*, L. Cen*, Microfluidic preparation of PLGA composite microspheres with mesoporous silica nanoparticles for finely manipulated drug release, International Journal of Pharmaceutics. 593 (2021) DOI10.1016/j.ijpharm.2020.120173.
6. T. Zhou, S. Chen, X. Ding, Z. Hu, L. Cen*, X. Zhang*. Fabrication and Characterization of Collagen/PVA Dual-Layer Membranes for Periodontal Bone Regeneration. Frontiers in Bioengineering and Biotechnology. 9 (2021)https://doi.org/10.3389/fbioe.2021.630977.
7. H. Wu, L. Shen, Z. Zhu, X. Luo, Y. Zhai, X. Hua, S. Zhao, L. Cen*, Z. Zhang*, A cell-free therapy for articular cartilage repair based on synergistic delivery of SDF-1 & KGN with HA injectable scaffold, Chemical Engineering Journal. 393 (2020) DOI10.1016/j.cej.2020.124649.
8. C. Zhu, H. Yang, L. Shen, Z. Zheng, S. Zhao, Q. Li, F. Yu, L. Cen?,Microfluidic preparation of PLGA microspheres as cell carriers with sustainable Rapa release. Journal of Biomaterials Science-Polymer Edition. 30 (2019) 737-755.
9. H. Chen, F. Jia, C. Zhu, J. Xu, X. Hua, Z. Xi, L. Shen, S. Zhao, L. Cen?,Controllable preparation of SB-3CT loaded PLGA microcapsules for traumatic-brain-injury pharmaco-therapy,Chemical Engineering Journal. 339 (2018) 346-358.
10. C. Zhu, R. Yang, X. Hua, H. Chen, J. Xu, R. Wu *, L. Cen *, Highly stretchable HA/SA hydrogels for tissue, Journal of Biomaterials Science-Polymer Edition. 29 (2018) 543-561.
11. J. Zhang, S. Yang, X. Yang, Z. Xi*, L. Zhao, L. Cen*, E.Y. Lu, Y. Yang, Novel fabricating process for porous polyglycolic acid scaffolds by melt-foaming using supercritical carbon dioxide, ACS Biomaterials Science & Engineering. 4 (2018) 694-706.
12. Z. Sun, S. Liu, K. Li, L. Tan, L. Cen*, G. Fu*, Well-defined and biocompatible hydrogels with toughening and reversible photoresponsive properties, Soft Matter. 12 (2016) 2192-2199.
13. R. Yang, L. Tan, L. Cen*, Z. Zhang*, An injectable scaffold based on crosslinked hyaluronic acid gel for tissue regeneration, RSC Advances. 6 (2016) 16838-16850.
14. Y. Zhu, H. Chen, L. Cen*, J. Wang*, Influence of abutment tooth position and adhesive point dimension on the rigidity of a dental trauma wire-composite splint, Dental Traumatology. 32 (2016) 225-230.
15. M. Dong, S. Liu, L. Tan, L. Cen*, G. Fu*, Hydrogels of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks, Chinese Journal of Polymer Science. 34 (2016) 637-648.
16. W. Zhu, Q. Zhang, Y. Zhang, L. Cen*, J. Wang*, PDL regeneration via cell homing in delayed replantation of avulsed teeth, Journal of Translational Medicine. 13 (2015) 357.
17. L. Tan, J. Wang, S. Yin, W. Zhu, G. Zhou, Y. Cao*, L. Cen*, Regeneration of dentin–pulp-like tissue using an injectable tissue engineering technique, RSC Advances. 5 (2015) 59723-59737.
18. Y. Li, C. Zhou, L. Xu, F. Yao, L. Cen*, et al, Stimuli-responsive hydrogels prepared by simultaneous click chemistry and metal-ligand coordination, RSC Advances. 5 (2015) 18242-18251.
19. S.S Qian, C. Zhou, L. Xu, L. Cen*, et al, High strength biocompatible PEG single-network hydrogels, RSC Advances. 4 (2014) 25241-25250.
20. Y.W. Sun, C. Zhou, A.K. Zhang, L.Q. Xu, F. Yao, L. Cen*, et al, The synthesis of hydrogels with controlled distribution of polymer brushes on hydrogel network, Applied Surface Science. 320 (2014) 818-828.
21. F. Jia, Y.H. Yin, G.Y. Gao, Y. Wang, L. Cen*, et al, MMP-9 Inhibitor SB-3CT Attenuates Behavioral Impairments and Hippocampal Loss after Traumatic Brain Injury in Rat, Journal of Neurotrauma. 31 (2014) 1225-1234.
22. S. Xie, Q. Zhu, B. Wang, H. Gu, W. Liu, L. Cui, L. Cen*, et al, Incorporation of tripolyphosphate nanoparticles into fibrous poly(lactide-co-glycolide) scaffolds for tissue engineering, Biomaterials. 31 (2010) 5100.-5109
23. Z. Li, L. Cen*, L. Zhao, et al,Preparation and evaluation of thiolated chitosan scaffolds for tissue engineering, Journal of Biomedical Materials Research A.92A (2010) 973–978.
24. L. Cen, K.G. Neoh, J. Sun, et al, Labeling of adipose derived stem cells by oleic acid modified magnetic nanoparticles, Advanced Functional Materials. 19 (2009) 1158-1166.
25. L. Cen, W. Liu, L. Cui, Y. Cao, Collagen tissue engineering: development of novel biomaterials and applications, Pediatric Research. 63 (2008) 492-496.
26. L. Cen, K.G. Neoh, E.T. Kang, Au-Pt bimetallic nanoparticles formation via viologen-mediated reduction on polymeric nanospheres, Journal of Colloid and Interface Science. 300 (2006) 190-199.
27. L. Cen, K.G. Neoh, E.T. Kang, Gold nanocrystal formation on viologen functionalized polymeric nanospheres, Advanced Materials. 17 (2005)1656-1661.
28. L. Cen, K.G. Neoh, Y.L. Li, E.T. Kang, Assessment of in vitro bioactivity of hyaluronic acid and sulfated hyaluronic acid functionalized electroactive polymer, Biomacromolecules. 5 (2004) 2238-2246.
29. L. Cen, K.G. Neoh, E.T. Kang, Antibacterial activity of cloth functionalized with n-alkylated poly(4-vinylpyridine), Journal of Biomedical Materials research A. 71A (2004) 70-80.
30. L. Cen, K.G. Neoh, E.T. Kang, L. Ying, Surface modification of polymeric films and membranes to achieve antibacterial properties, Surface and Interface Analysis. 36 (2004) 716-719.
31. L. Cen, K.G. Neoh, E.T. Kang, Surface functionalization of polypyrrole film with glucose oxidase and viologen, Biosensors & Bioelectronics. 18 (2003) 363-374.
32. L. Cen, K.G. Neoh, E. Kang, Surface functionalization technique for conferring antibacterial properties to polymeric and cellulosic surfaces, Langmuir. 19 (2003) 10295-10303.
33. L. Cen, K.G. Neoh, E. Kang, Surface functionalization of electrically conductive polypyrrole film with hyaluronic acid, Langmuir. 18 (2002) 8633-8640.